Toxicologists study the harmful effects of
chemical, physical and biological agents on living organisms by detecting
and examining the symptoms, mechanisms and treatments of poisoning
(especially the poisoning of people).
They also determine safe or acceptable levels of exposure to particular
agents.
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Specialisations:
Analytical Toxicologist- identifies and measures toxic
agents in biological and environmental samples to determine the extent of
exposure (after poisoning or a chemical spill, or during long-term
environmental contamination, for example) and to monitor the remediation of
chemical spills.
Clinical Toxicologist- has medical qualifications to study
the harmful effects of chemicals, drugs, pesticides and other substances on
humans through the clinical diagnosis of symptoms and biological poisoning.
Clinical toxicologists also treat and manage intoxicated patients.
Environmental Toxicologist/Ecotoxicologist- studies the
harmful effects of environmental exposure to chemical, physical and
biological agents on living organisms (including their effects on humans,
fish, other animals and plants), as well as their effects on ecosystems.
Occupational Toxicologist
- studies the harmful effects of
substances used in the workplace to determine a safe or acceptable level of
exposure to workers, as well as appropriate control measures to reduce or
eliminate worker exposure.
Regulatory Toxicologist- has the primary role of ensuring
public health and safety from the use of chemicals, drugs and pesticides by
identifying potential health risks posed by exposure to such substances.
Regulatory toxicologists provide advice to governments, health
professionals, politicians and the public on potential risks associated with
chemical exposure so that appropriate risk management strategies may be
implemented to protect the health of workers and the public.
Knowledge, skills and attributes
enjoy and have an aptitude for science and
research
study the amount of exposure to a substance
(from pollution caused by environmental contaminants such as industrial
waste products or emergency events such as a gas leak, for example) and
the potential effect it may have on public health, plants, animals and
the ecosystem
study how exposure to foreign chemicals affects
the genetic, chemical, physical and structural composition of cells,
tissues, organ systems and whole organisms
devise and carry out experiments to determine
how chemical or drug concentrations in the body change over time
test newly discovered or manufactured substances
for their safety, effects and possible use as drugs
analyse blood, urine and other biological and
environmental samples to identify the chemical composition and
concentration of drugs, contaminants and other substances
evaluate evidence from cases where tampering and
contamination has occurred
write scientific reports on research and
investigations, as well as more general information for scientific,
managerial, political and general audiences
document results, preserve evidence and maintain
chain of custody (the document or paper trail showing the process from
evidence seizure through to the presentation of the evidence in court)
in criminal investigations
provide advice to managers, politicians, primary
producers, healthcare workers, the general public and community groups
Education and training/entrance requirements
To become a toxicologist you usually have to complete a relevant science or
forensics degree at university with a major in toxicology.
Toxicologists are employed across several industries, including
pharmaceutical, food and chemical industries, environmental management,
scientific research, government regulatory agencies, and other research
organisations and health services. They are also employed in hospitals and
educational institutions.
The term
"forensics" means "of or having to do with a question of law." Forensic
toxicologists are simply toxicologists who apply their knowledge to legal
matters. They play a crucial role in solving crimes and helping to determine
causes of death.
Forensic
toxicologists play an important role in determining how certain substances
affect human bodies. Their work often benefits the medical field, law
enforcement and individuals who have lost loved ones. A forensic
toxicologist is a scientist who performs specialized tests to examine tissue
samples and bodily fluids for drugs or other chemicals. Through their
research, they can help law enforcement officials determine what happened at
the scene of accidents or medical emergencies. They can also contribute to
the medical field by determining how substances impact the health of
individuals and society. Families, investigtors and legal experts often rely
on forensic toxicologists to determine how or why an individual died.
A number of
crimes involve toxins entering the body, such as poisoning, driving under
the influence, and using illegal drugs. Detectives and criminal
investigators seek help from forensic toxicologists to get the answers they
need when they suspect that a chemical substance is related to a crime.
Forensic toxicologists perform scientific tests on bodily fluids and tissue
samples to identify any drugs or chemicals present in the body. Crime Scene
Investigators rely on the forensic toxicologist to make reliable conclusions
about the impact a specific amount of a specific substance would have on a
specific individual. Often, this requires the professional to form an
educated opinion based on science and experience.
A Forensic Toxicologist specialises in the study of
alcohol, legal and illicit drugs, and poisons, including their chemical
composition, preparation and identification. Forensic toxicologists also
study the absorption, distribution and elimination characteristics of
chemicals and substances in the body, as well as the way in which the body
responds to them and the factors that determine drug safety and
effectiveness.
Forensic toxicology involves working with sensitive
materials in potentially hazardous environments. To avoid the potential
dangers associated with the field and perform well in the role, you may
benefit from developing certain skills. Common skills for a forensic
toxicologist include:
Critical thinking: Using critical thinking
skills helps forensic toxicologists make accurate findings.
Attention to detail: Paying attention to detail
can prevent dangerous or costly errors.
Knowledge of chemistry: Understanding chemical
structures and reactions can ensure forensic toxicologists handle
samples and equipment safely.
Clinical methodology: Working in a forensic
toxicology lab requires a scientific approach that allows professionals
to function separately from their emotions.
Communication skills: Excellent written and
verbal communication skills, as they may be called upon to provide
courtroom testimony. Forensic toxicologists
often communicate their findings with officials such as health care
providers, law enforcement officers, lawyers and judges.
Patience, efficiency, and focus to gather
results under pressure
Forensic toxicologists test samples of human tissue
to determine if they're affected by a substance. If a substance is found,
they work to understand how it impacted the person's health or behaviour.
They typically work at law enforcement facilities, medical examiner's
offices or private establishments like drug testing laboratories.
Some primary duties of a forensic toxicologist include:
Testing tissues
such as bodily fluids for drugs, alcohol, chemicals, gases and other
substances. Identifying unknown substances by
testing samples using chromatography, spectrometry, or other
chemical tests
Measuring the concentration of substances
within the tissues. Reviewing autopsy reports and
performing toxicological tests on blood and tissue samples from
deceased persons to determine the cause of death
Researching the effects of alcohol or
substance consumption under specific circumstances.
Interpreting data from drug test results, including blood alcohol
levels and drug concentrations in urine, blood, or other body fluids
Collecting and testing for harmful
contaminants in food, drink or the
environment. Conducting lab tests to identify
illegal drugs such as cocaine, heroin, amphetamines, and cannabis
products such as hashish and marijuana
Using chemical and biomedical
instrumentation
Informing law enforcement officers about the
presence of substances or alcohol in an individual's system
Working with medical examiners to determine
if substances contributed to a person's death
Helping environmental professionals measure
the effects of certain chemicals on people and wildlife
In the law enforcement sphere, forensic
toxicologists might work for criminal justice agencies, police
departments, or government labs. They might look for poisons and
toxins such as alcohol, drugs, metals, chemicals, and gases.
Sometimes, the toxicologist's findings are the primary factor in
determining whether a crime was committed.
Providing expert witness testimony in court
proceedings
Most forensic toxicologists work in labs run by law
enforcement agencies, medical examiners or private drug testing facilities.
They often must sit or stand for long periods of time. The lab is usually
run by a private drug testing company, a medical examiner's office, or the
police. You may also spend part of your day working out in the field, such
as at a crime scene collecting samples.
The tests they perform require very fine motor skills and a dogged
commitment to following rigorous scientific protocols.
Working with bodily fluids and tissue samples can be messy and smelly. The
forensic toxicologist is also exposed to details about crimes, which can be
emotionally difficult.
Expect to work 40 to 60 hours a week, as you manage a heavy workload under
stringent deadlines. Hours need to be flexible, as forensic toxicologists
are expected to be on call to collect and analyze evidence. In addition,
working out in the field visiting crime scenes may also require extended or
unusual hours.
The workload can be significant, and when the
samples come from a crime scene, the pressure to perform tests faster can be
strong. The forensic toxicologist must be able to resist this pressure, work
efficiently without rushing and prioritize effectively.
Tools and technologies The forensic toxicologist performs tests on
samples collected by forensic pathologists during an autopsy or by crime
scene investigators. They use highly sophisticated instruments, chemical
reagents and precise methodologies to determine the presence or absence of
specific substances in the sample.
As part of a team investigating a crime, a forensic toxicologist will
isolate and identify any substances in the body that may have contributed to
the crime, such as:
Alcohol
Illegal or prescription drugs
Other chemicals
Poisons
Metals
Gases, such as carbon monoxide
The work requires patience and the ability to follow specific steps to
achieve reliable results. The forensic toxicologist must document every step
of the process and take care to follow rules regarding chain of custody for
physical evidence.
Education and training/entrance requirements
A forensic toxicologist generally
has a bachelor’s degree in chemistry, clinical chemistry, pharmacology or
another scientific field. Courses you might consider as part of your degree
program include:
Toxicology
Forensic Science
Statistics
Data Analysis
Anatomy
Some universities now offer
master’s degrees and doctoral degrees in forensic toxicology. Eg. Murdoch
University; Griffith University; Monash University; UTS; University of
Canberra; UNE.
Forensic toxicologists receive
most of their training through their educational programs. They may also
receive on-the-job training in their roles as forensic toxicologists. This
training may include learning about the laboratory’s policies and
procedures, the equipment they use and the software they employ.
As the science of forensic
toxicology is constantly advancing, the forensic
toxicologist has to keep pace with new technologies, methodologies and
chemicals and this demands constant learning.
Forensic toxicologists will also
need to conduct experiments to develop new techniques for detecting drugs or
other substances in body fluids. They will have to conduct research on new
drugs that may pose a danger to society, such as designer drugs ( designer
drugs ) like bath salts or synthetic marijuana.
Employment Opportunities
The employment of forensic
toxicologists is expected to grow much faster than average over the next
decade.
The need to identify and prosecute drug traffickers will continue to drive
demand for forensic toxicologists. As the use of new drugs increases, these
specialists will be needed to identify the types and amounts of drugs
present in biological samples.
The field of forensic toxicology has grown to include drug and alcohol
testing for employers and traffic enforcement officials as well as testing
animal samples for wildlife criminal investigators and testing for “date
rape” drugs and performance-enhancing substances.
Forensic
toxicologists also work on cases involving environmental contamination, to
determine the impact of chemical spills on nearby populations.
"Real stories of life and death: why forensic toxicology is nothing
like TV" - taken directly from
Health Qld
The Hollywood interpretation of forensics is played out on TV shows
like CSI Miami where detectives, like Horatio Caine, stride around
crime scenes in suits and sunglasses spitting out fast one liners
and the labs are filled with more technology than Star Wars.
In the real world, forensic work involves real people and real
stories of life and death, and is a far cry from the examples set by
TV shows, as Amanda Thompson explains.
Forensic toxicologist Amanda Thompson
shares a behind-the-scenes look at forensic work.
I’m a senior chemist with the Forensic Toxicology department at
Queensland Health’s Forensic and Scientific Services (FSS).
Primarily, my job is about the detection of drugs and alcohol in
biological specimens—blood, urine, saliva, hair, liver—as well as
other samples from post-mortems.
Most of our samples come from the Queensland Police Service and the
Coroner’s office. For the police, there may be saliva samples
collected during roadside drug testing, or blood samples from people
suspected of driving under the influence of drugs. Other samples
come from autopsies around the state and we’ll examine the samples
to see if drugs were involved in a death. Or in some cases, we might
be looking to see if a drug is absent. For example, if a deceased
person was meant to be taking anti-depressants, the absence of the
drug can be an important finding.
Forensic toxicologist Amanda Thompson
wears a lab coat and stands in a workplace signed 'Bio Hazard Area
We work closely with other teams at FSS like Forensic Pathology and
Forensic Chemistry to make sure we’re across the changes in drugs
people are taking, so we know what we’re testing for. Some of the
so-called ‘legal highs’ have become more popular in recent years,
and while they may not be detected in standard workplace drug tests,
we have a range of cutting-edge techniques that will pick up most
things.
When shows like CSI and NCIS were at their peak, there was an
increased interest in this field and it became a more competitive
field to get into. Some hearty competition is always welcome in a
field like forensics because it helps bring some of the best and
brightest minds into science.
However, those shows don’t accurately reflect what we do as our work
is very detailed and takes more time than people may realise.
For example, if we are testing for drugs, we first have to extract
the drugs out of whatever specimen we’ve received. If it’s a blood
sample, it can take a few hours to separate the drugs from the blood
and the other stuff mixed in there. From there, it’s run overnight
on a machine to analyse before we can produce the results.
Most people working in forensics specialise in one area—toxicology,
or DNA for example—we’re generally not multi-disciplinarians. For
anyone worried about monotony setting in, please don’t. There is
always something interesting to discover.
Although this is an extremely rewarding job, it can also be a
challenging job. But I remind myself I’m doing something to help a
person, and their family and friends. My work may be able to provide
answers which contribute to determining the cause of death or help
provide evidence to support police investigations.
Knowing that there is always someone somewhere looking for answers
and the results we’re producing helps provide those answers is a
rewarding feeling (Source: Health Qld)
Toxinology is the specialized area of toxicology that
deals specifically with animal, plant and microbial toxins, but is also
considered a science in its own right.
Toxinology includes more than just the chemistry and
mode of action of a toxin. It deals also with the biology of venom- or
poison-producing organism, the structure and function of the venom apparatus
as well as the use of the venom or poison, the ecological role of these
compounds.
Toxins are natural substances, or substances produced
by living organisms, in contrast to toxic substances from chemicals, which
are toxicants. Living organisms producing or using toxins do so as either
venoms or poisons. Venoms are toxins, or more commonly, collections of
varying toxins, that are used actively against prey or predators, most
commonly to subdue, kill and digest prey, or disuade predators. Poisons of
natural origin, that is containing toxins and used by living organisms, are
passive and generally used for defence. A predator attempting to molest or
eat a poisonous animal, plant or mushroom will suffer adverse effects from
the toxins in the poison, varying from mild discomfort to rapid death.
Particularly food poisons, but also for a few venoms, the component toxins
are not produced by the deploying animal/plant, but are made by
micro-organisms and concentrated and used by the deploying animal/plant. A
good example is tetrodotoxin, used by a variety of poisonous animals and by
a few venomous animals.
Toxinologists study toxins, such as venoms and poisons,
and the living organisms that produce them, including plants, fungi,
microbes and various animals. They research the chemical structure and
functions of toxins and explore the biological activities of toxin-producing
organisms, like scorpions, snakes and spiders.
A toxinologist's work might focus specifically on improving ways to treat
victims of venomous snakebites or jellyfish stings, or he or she might
research ways toxins can be purified and cloned for use as medical therapies
in patients recovering from strokes or heart attacks or those fighting
cancer.
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Specialisations: Clinical Toxinologist - who focus
on the medical effects in humans of exposure to the toxins in animal venoms
or plant poisons. This includes such problems as venomous snakebite,
currently considered to afflict >2.5 million people each year, with >100,000
deaths.
Knowledge, skills and attributes
Toxinologists need analytical skills so they can conduct accurate, precise
experiments in the lab, along with problem-solving and critical-thinking
skills to help them formulate answers to tough scientific queries. They also
need to exercise diligence since they'll be working with potentially
dangerous organisms and their toxins.
Did You Know?
If something is a toxin, you can call it toxic. But, of course, this
is where things get a bit tricky: while the word toxin only refers
to substances that are toxic in low doses, the adjective toxic can
be used whenever something causes disease. You can have toxic
amounts of water, but water is never considered a toxin. Hence the
term toxinology as opposed to toxicology: the latter is the study of
adverse effects that occur in living organisms due to chemicals,
period. Any chemical in that causes harm no matter how large or
repeated a dose required might be examined by toxicologists, while
toxinolgists specialize on biologically-produced substances
(“biotoxins”) that wreak havoc in small amounts and the biology and
ecology of the organisms that wield them.
Toxins can be further categorized by where they come from. Usually,
toxins that are made synthetically are called toxicants, as opposed
to the general term toxins, which occur in nature.
Biological toxins are produced by living creatures, while
environmental toxins are not (things like lead and arsenic, for
example). Toxins also get classified by what they do, especially to
us; hemotoxins are toxins that act on the blood, while neurotoxins
attack nerves. And then there are subcategories of toxins based on
how they enter the body. Oral toxins, for example, are toxins that
cause harm when ingested, while topical toxins or are those that are
harmful if applied to the skin. Some toxins are harmless if
swallowed, but lethal if injected, so the route of entry can matter
greatly. In fact, route of entry is so important that toxinologists
use entirely separate words to refer to toxins based on delivery:
venoms and poisons.
Some toxins act when ingested, absorbed through the skin, or
inhaled; such toxins are referred to as poisons. Others enter our
bodies through wounds deliberately inflicted by the toxic
species—those are venoms.
Essentially boils down to who the aggressor is: the toxic species
(venoms) or the one who suffers the effects of the toxins (poisons).
The difference between poison and venom is why toxinologists cringe
every time they see someone referring to a “poisonous snake.”
Toxins are substances that cause harm in small amounts. There are
three main types of toxins:
* venoms,
*poisons and
*toxungens,
which differ based on route of delivery
Toxungens are poisons that are aggressively wielded, like the
squirting of poison by cane toads or spitting of venom by certain
cobra species. Since no wound is inflicted when the toxins are
sprayed, they aren’t considered “venoms” in context, but the animals
aren’t exactly waiting to be harassed, either. Because the toxic
species is actively involved in the delivery of its noxious
chemicals, but they aren’t making wounds, we give them a special
category all to themselves.